P. Leslie Dutton
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Department: 
Medical School/ Biochem. Biophys.

Research Interests:

  • Biological Electron Transfer
  • Synthetic Proteins - Maquettes

Research Overview: Dr. Dutton strives to understand elementary processes of oxidation-reduction and diverse biological events coupled to it, and to define the thresholds of oxidative failure potentiating pathogenesis.

Thirty percent of the nature's enzymes are oxidoreductases. They cover a wide range of biological functions including gene regulation, signalling, long range electron transfer, energy conversion (in photosynthesis and respiration), atom transport, drug detoxification, and a wide range of enzyme catalysis. Using a battery of physical, chemical and computational methods applied to a variety of oxidoreductases and redox proteins, the Dutton lab focuses on how biology controls the direction and speed of electron transfer with high fidelity over large distances through proteins: that is, which parameters drawn from quantum mechanical electron tunneling theory have been selected to engineer oxidoreductases.

Understanding electron tunnelling provides the foundation to investigate how biological redox reactions are coupled to the chemical events of proton exchange, protein conformation central to chemical catalysis signal transduction, and energy conversion.

Les Dutton's Recent Publications

Education:
Ph.D. University of Wales (1967) Biochemistry
University of Wales, Chemistry, B.Sc., 1963

Honors and Awards: The First Sir William Dunn Scholar, Cambridge ('07) - Randolph T. Major Medal: Merck & Company and The University of Connecticut ('06) - Frontiers in Biological Chemistry Award: Max Planck Institute Mulheim, Germany ('02) - Senior Visiting Fellowship, St. John's College, Oxford ('01) - John Morgan Society ('99) - IBM Partnership Award ('95) - Keilin Medal of the Biochemical Society ('94) - Peter Mitchell, Glynn Medal ('94) - Fellow of the University College, University of Wales ('94) -Eldridge Reeves Johnson Professor ('91) - Fellow of the Royal Society ('90)